{"id":1,"date":"2026-06-20T09:03:59","date_gmt":"2026-06-20T09:03:59","guid":{"rendered":"https:\/\/cancercurecase.com\/?p=1"},"modified":"2026-06-21T13:49:06","modified_gmt":"2026-06-21T13:49:06","slug":"hello-world","status":"publish","type":"post","link":"https:\/\/cancercurecase.com\/?p=1","title":{"rendered":"1. Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured"},"content":{"rendered":"<div class=\"woocommerce \"><ul class=\"products columns-4\">\r\n<li class=\"product type-product post-24 status-publish first instock product_cat-uncategorized has-post-thumbnail sale downloadable virtual purchasable product-type-simple\">\n\t<a href=\"https:\/\/cancercurecase.com\/?product=pdflink\" class=\"woocommerce-LoopProduct-link woocommerce-loop-product__link\">\n\t<span class=\"onsale\">Sale!<\/span>\n\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-300x300.png\" class=\"attachment-woocommerce_thumbnail size-woocommerce_thumbnail\" alt=\"Download PDF\" srcset=\"https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-300x300.png 300w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-100x100.png 100w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-150x150.png 150w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon.png 440w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><h2 class=\"woocommerce-loop-product__title\">1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured<\/h2>\n\t<span class=\"price\"><del aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\"><bdi><span class=\"woocommerce-Price-currencySymbol\">&#36;<\/span>99.00<\/bdi><\/span><\/del> <span class=\"screen-reader-text\">Original price was: &#036;99.00.<\/span><ins aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\"><bdi><span class=\"woocommerce-Price-currencySymbol\">&#36;<\/span>69.00<\/bdi><\/span><\/ins><span class=\"screen-reader-text\">Current price is: &#036;69.00.<\/span><\/span>\n<\/a><a href=\"\/index.php?rest_route=%2Fwp%2Fv2%2Fposts%2F1&#038;add-to-cart=24\" aria-describedby=\"woocommerce_loop_add_to_cart_link_describedby_24\" data-quantity=\"1\" class=\"button product_type_simple add_to_cart_button ajax_add_to_cart\" data-product_id=\"24\" data-product_sku=\"\" aria-label=\"Add to cart: &ldquo;1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured&rdquo;\" rel=\"nofollow\" data-success_message=\"&ldquo;1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured&rdquo; has been added to your cart\" role=\"button\">Add to cart<\/a>\t<span id=\"woocommerce_loop_add_to_cart_link_describedby_24\" class=\"screen-reader-text\">\n\t\t\t<\/span>\n<\/li>\n<\/ul>\n<\/div>\n<h5>Please Buy the PDF full text in English, along with translations in Chinese, Hindi, Indonesian, Arabic, Spanish, Portuguese, and French.<\/h5>\n\n\n<p class=\"wp-block-paragraph\">Glioblastoma is the deadliest type of brain tumor with limited effective therapies over decades. Its growth and recurrence rely heavily on glioblastoma stem cells (GSCs), which resist standard chemo-radiotherapy. Bone Morphogenetic Protein 4 (BMP4) can push these malignant stem cells to mature and lose their tumor-forming ability in lab and animal models. This paper reports the world\u2019s first human Phase 1 trial testing locally injected human recombinant BMP4 (hrBMP4) as a differentiation-based anti-cancer therapy for recurrent glioblastoma.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This international multi-center open-label trial used a standard 3+3 dose-escalation design, enrolling 15 adult patients whose glioblastoma had returned after standard chemoradiation. Eligible patients had decent daily function (Karnofsky score &gt;70) and limited brain swelling. Doctors implanted fine catheters into and around tumors for Convection Enhanced Delivery (CED)\u2014a slow, pressure-driven infusion that spreads drugs deep into brain tissue better than regular injections. Five dose groups (0.5 mg to 18 mg hrBMP4, three patients each) received continuous infusion over 4\u20136 days. Researchers tracked safety, maximum tolerable dose (MTD), blood hrBMP4 levels, MRI tumor changes, survival, and quality of life for up to 57 months.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The treatment proved very safe overall. No drug-related severe toxicities or dose-limiting side effects emerged, so MTD was not reached. Most mild-to-moderate symptoms (headache, vomiting, weakness) stemmed from catheter surgery or steroid drugs, not hrBMP4. Only three patients had temporarily elevated blood hrBMP4 that returned to normal within four weeks without harm.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Notably, 3 out of 15 patients showed lasting tumor shrinkage, including two complete local tumor responders with exceptional long-term survival. Patient 2 received the lowest 0.5 mg hrBMP4 dose for a second recurrent temporal glioblastoma. After infusion, the treated tumor slowly shrank steadily over 12 months with no new tumor growth. At the 57-month follow-up, the patient remained clinically stable with improved movement and balance, and never needed extra chemo or surgery afterward. Patient 15 got the highest 18 mg hrBMP4 dose for a treatment-resistant parietal lobe recurrence. The lesion regressed gradually over 18 months and achieved full radiological clearance. Thirty months post-treatment, this injected tumor area stayed completely gone, even though a separate untreated frontal tumor later progressed. The third responder only had partial tumor shrinkage before later progression. Another key finding: tumor regrowth almost always happened outside brain regions covered by hrBMP4 infusion, while drug-permeated zones rarely saw new tumor growth. Median overall survival across all patients hit 7 months, longer than the typical 5.6 months from common second-line lomustine chemotherapy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This pioneering first-in-human study confirms local hrBMP4 via CED is safe and tolerable for recurrent glioblastoma. The two long-term complete remissions strongly validate differentiation therapy targeting GSCs. Its main limitations are incomplete tumor coverage by CED catheters and lack of pre-trial molecular patient screening. The promising anti-tumor signals support launching larger Phase 2 trials to formally test hrBMP4\u2019s therapeutic power, with technical improvements to boost drug coverage and predictive biomarkers to select patients most likely to respond.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"870\" height=\"884\" src=\"https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/ccc-1-complete-response.png\" alt=\"\" class=\"wp-image-68\" srcset=\"https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/ccc-1-complete-response.png 870w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/ccc-1-complete-response-295x300.png 295w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/ccc-1-complete-response-768x780.png 768w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/ccc-1-complete-response-600x610.png 600w\" sizes=\"auto, (max-width: 870px) 100vw, 870px\" \/><\/figure>\n\n\n\n<h5>\u4e2d\u56fd\u7528\u6237\u8bf7\u901a\u8fc7\u652f\u4ed8\u5b9d\u8d2d\u4e70PDF\u82f1\u8bed\u5168\u6587\u53ca\u5176\u4e2d\u6587\u7ffb\u8bd1\u4ef6\u3002<\/h5>\n\n\n<h2 class=\"wp-block-heading\"><strong>hrBMP4\u5c40\u90e8\u7ed9\u836f\u6cbb\u7597\u590d\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624: 2\u4f8b\u5b8c\u5168\u80bf\u7624\u6d88\u5931<\/strong><br><\/h2>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u6574\u4f53\u800c\u8a00\uff0c\u8be5\u6cbb\u7597\u65b9\u6848\u5b89\u5168\u6027\u826f\u597d\u3002\u8bd5\u9a8c\u672a\u51fa\u73b0\u4e0e\u836f\u7269\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff0c\u4e5f\u672a\u89c2\u6d4b\u5230\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff0c\u56e0\u6b64\u672a\u786e\u5b9a\u6700\u5927\u8010\u53d7\u5242\u91cf\u3002\u591a\u6570\u8f7b\u3001\u4e2d\u5ea6\u4e0d\u826f\u53cd\u5e94\uff08\u5934\u75db\u3001\u5455\u5410\u3001\u80a2\u4f53\u65e0\u529b\uff09\u5747\u7531\u5bfc\u7ba1\u690d\u5165\u624b\u672f\u6216\u6fc0\u7d20\u7c7b\u8f85\u52a9\u836f\u7269\u5f15\u53d1\uff0c\u5e76\u975ehrBMP4\u672c\u8eab\u6240\u81f4\u3002\u4ec53\u540d\u60a3\u8005\u8f93\u6ce8\u540e\u5916\u5468\u8840hrBMP4\u6d53\u5ea6\u77ed\u6682\u5347\u9ad8\uff0c4\u5468\u5185\u81ea\u884c\u56de\u843d\u81f3\u57fa\u7ebf\u6c34\u5e73\uff0c\u4e14\u672a\u4f34\u968f\u4efb\u4f55\u6bd2\u526f\u4f5c\u7528\u3002<\/p>\n\n\n\n<p 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hrBMP4\u6cbb\u7597\u3002\u7ed9\u836f\u540e\uff0c\u75c5\u7076\u572812\u4e2a\u6708\u5185\u6301\u7eed\u7f13\u6162\u7f29\u5c0f\uff0c\u65e0\u65b0\u53d1\u80bf\u7624\uff1b\u968f\u8bbf\u81f357\u4e2a\u6708\u65f6\uff0c\u60a3\u8005\u8eab\u4f53\u72b6\u6001\u7a33\u5b9a\uff0c\u80a2\u4f53\u6d3b\u52a8\u3001\u884c\u8d70\u5e73\u8861\u80fd\u529b\u8f83\u6cbb\u7597\u524d\u663e\u8457\u6539\u5584\uff0c\u5168\u7a0b\u65e0\u9700\u8ffd\u52a0\u5316\u7597\u6216\u4e8c\u6b21\u624b\u672f\u300215\u53f7\u60a3\u8005\u9876\u53f6\u80bf\u7624\u591a\u6b21\u5316\u7597\u65e0\u6548\uff0c\u5c5e\u4e8e\u590d\u53d1\u96be\u6cbb\u75c5\u7076\uff0c\u63a5\u53d7\u6700\u9ad8\u5242\u91cf18mg 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class=\"wp-block-paragraph\">\u8fd9\u9879\u5f00\u521b\u6027\u9996\u4eba\u4f53\u8bd5\u9a8c\u8bc1\u5b9e\uff0c\u7ecf\u5bf9\u6d41\u589e\u5f3a\u9012\u9001\u6280\u672f\u5c40\u90e8\u8f93\u6ce8hrBMP4\u7528\u4e8e\u590d\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u5b89\u5168\u3001\u8010\u53d7\u6027\u4f73\u3002\u4e24\u4f8b\u957f\u671f\u80bf\u7624\u5b8c\u5168\u7f13\u89e3\u7684\u75c5\u4f8b\uff0c\u6709\u529b\u8bc1\u5b9e\u4e86\u9776\u5411\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u5e72\u7ec6\u80de\u7684\u5206\u5316\u7597\u6cd5\u5177\u5907\u4e34\u5e8a\u6f5c\u529b\u3002\u7814\u7a76\u5b58\u5728\u4e24\u70b9\u4e3b\u8981\u5c40\u9650\uff1a\u5bf9\u6d41\u7ed9\u836f\u5bfc\u7ba1\u65e0\u6cd5\u5b9e\u73b0\u80bf\u7624\u5168\u57df\u8986\u76d6\uff0c\u4e14\u5165\u7ec4\u524d\u672a\u4f9d\u636e\u80bf\u7624\u5206\u5b50\u5206\u578b\u7b5b\u9009\u60a3\u8005\u3002\u672c\u6b21\u8bd5\u9a8c\u5c55\u73b0\u51fa\u53ef\u89c2\u7684\u6297\u80bf\u7624\u7597\u6548\u4fe1\u53f7\uff0c\u652f\u6301\u5f00\u5c55\u66f4\u5927\u89c4\u6a21\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7cfb\u7edf\u9a8c\u8bc1hrBMP4\u7684\u6cbb\u7597\u4ef7\u503c\uff1b\u540e\u7eed\u53ef\u4f18\u5316\u7ed9\u836f\u6280\u672f\u63d0\u5347\u836f\u7269\u8986\u76d6\u8303\u56f4\uff0c\u540c\u65f6\u7b5b\u9009\u751f\u7269\u6807\u5fd7\u7269\uff0c\u7cbe\u51c6\u7b5b\u9009\u66f4\u6613\u4ece\u8be5\u7597\u6cd5\u83b7\u76ca\u7684\u60a3\u8005\u3002<\/p>\n\n\n<div class=\"woocommerce \"><ul class=\"products columns-4\">\r\n<li class=\"product type-product post-24 status-publish first instock product_cat-uncategorized has-post-thumbnail sale downloadable virtual purchasable product-type-simple\">\n\t<a href=\"https:\/\/cancercurecase.com\/?product=pdflink\" class=\"woocommerce-LoopProduct-link woocommerce-loop-product__link\">\n\t<span class=\"onsale\">Sale!<\/span>\n\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-300x300.png\" class=\"attachment-woocommerce_thumbnail size-woocommerce_thumbnail\" alt=\"Download PDF\" srcset=\"https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-300x300.png 300w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-100x100.png 100w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-150x150.png 150w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon.png 440w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><h2 class=\"woocommerce-loop-product__title\">1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured<\/h2>\n\t<span class=\"price\"><del aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\"><bdi><span class=\"woocommerce-Price-currencySymbol\">&#36;<\/span>99.00<\/bdi><\/span><\/del> <span class=\"screen-reader-text\">Original price was: &#036;99.00.<\/span><ins aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\"><bdi><span class=\"woocommerce-Price-currencySymbol\">&#36;<\/span>69.00<\/bdi><\/span><\/ins><span class=\"screen-reader-text\">Current price is: &#036;69.00.<\/span><\/span>\n<\/a><a href=\"\/index.php?rest_route=%2Fwp%2Fv2%2Fposts%2F1&#038;add-to-cart=24\" aria-describedby=\"woocommerce_loop_add_to_cart_link_describedby_24\" data-quantity=\"1\" class=\"button product_type_simple add_to_cart_button ajax_add_to_cart\" data-product_id=\"24\" data-product_sku=\"\" aria-label=\"Add to cart: &ldquo;1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured&rdquo;\" rel=\"nofollow\" data-success_message=\"&ldquo;1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured&rdquo; has been added to your cart\" role=\"button\">Add to cart<\/a>\t<span id=\"woocommerce_loop_add_to_cart_link_describedby_24\" class=\"screen-reader-text\">\n\t\t\t<\/span>\n<\/li>\n<\/ul>\n<\/div>\n<h5>PDF \u0905\u0902\u0917\u094d\u0930\u0947\u091c\u0940 \u092a\u0942\u0930\u094d\u0923 \u092a\u093e\u0920 \u0914\u0930 \u0909\u0938\u0915\u093e \u0939\u093f\u0902\u0926\u0940 \u0905\u0928\u0941\u0935\u093e\u0926 \u0916\u0930\u0940\u0926\u0947\u0902\u0964<\/h5>\n\n\n<h1 class=\"wp-block-heading\">\u092a\u0941\u0928\u0930\u093e\u0935\u0943\u0924\u094d\u0924 \u0917\u094d\u0932\u093f\u092f\u094b\u092c\u094d\u0932\u093e\u0938\u094d\u091f\u094b\u092e\u093e \u0915\u0947 \u0932\u093f\u090f \u0938\u094d\u0925\u093e\u0928\u0940\u092f hrBMP4 \u0935\u093f\u0924\u0930\u0923 \u092a\u0930\u0940\u0915\u094d\u0937\u0923<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">\u0917\u094d\u0932\u093f\u092f\u094b\u092c\u094d\u0932\u093e\u0938\u094d\u091f\u094b\u092e\u093e \u092e\u0938\u094d\u0924\u093f\u0937\u094d\u0915 \u0915\u093e \u0938\u092c\u0938\u0947 \u0918\u093e\u0924\u0915 \u091f\u094d\u092f\u0942\u092e\u0930 \u0939\u0948, \u091c\u093f\u0938\u0915\u0947 \u0932\u093f\u090f \u0926\u0936\u0915\u094b\u0902 \u0938\u0947 \u092a\u094d\u0930\u092d\u093e\u0935\u0940 \u0909\u092a\u091a\u093e\u0930 \u0915\u0947 \u092c\u0939\u0941\u0924 \u0915\u092e \u0935\u093f\u0915\u0932\u094d\u092a \u0909\u092a\u0932\u092c\u094d\u0927 \u0939\u0948\u0902\u0964 \u0907\u0938\u0915\u0940 \u0935\u0943\u0926\u094d\u0927\u093f \u0914\u0930 \u092a\u0941\u0928\u0930\u093e\u0935\u0943\u0924\u094d\u0924\u093f \u092e\u0941\u0916\u094d\u092f \u0930\u0942\u092a \u0938\u0947 \u0917\u094d\u0932\u093f\u092f\u094b\u092c\u094d\u0932\u093e\u0938\u094d\u091f\u094b\u092e\u093e \u0938\u094d\u091f\u0947\u092e \u0915\u094b\u0936\u093f\u0915\u093e\u0913\u0902 (GSCs) \u092a\u0930 \u0928\u093f\u0930\u094d\u092d\u0930 \u0915\u0930\u0924\u0940 \u0939\u0948, \u091c\u094b \u092e\u093e\u0928\u0915 \u0915\u0940\u092e\u094b-\u0930\u0947\u0921\u093f\u092f\u094b\u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u093e \u092a\u094d\u0930\u0924\u093f\u0930\u094b\u0927 \u0915\u0930\u0924\u0940 \u0939\u0948\u0902\u0964 \u092a\u094d\u0930\u092f\u094b\u0917\u0936\u093e\u0932\u093e \u0914\u0930 \u092a\u0936\u0941 \u092e\u0949\u0921\u0932 \u092e\u0947\u0902 \u092c\u094b\u0928 \u092e\u0949\u0930\u094d\u092b\u094b\u091c\u0947\u0928\u0947\u091f\u093f\u0915 \u092a\u094d\u0930\u094b\u091f\u0940\u0928 4 (BMP4) \u0907\u0928 \u0918\u093e\u0924\u0915 \u0938\u094d\u091f\u0947\u092e \u0915\u094b\u0936\u093f\u0915\u093e\u0913\u0902 \u0915\u094b \u092a\u0930\u093f\u092a\u0915\u094d\u0935 \u0939\u094b\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u092a\u094d\u0930\u0947\u0930\u093f\u0924 \u0915\u0930 \u0938\u0915\u0924\u093e \u0939\u0948 \u0914\u0930 \u0909\u0928\u0915\u0940 \u091f\u094d\u092f\u0942\u092e\u0930 \u092c\u0928\u093e\u0928\u0947 \u0915\u0940 \u0915\u094d\u0937\u092e\u0924\u093e \u0938\u092e\u093e\u092a\u094d\u0924 \u0915\u0930 \u0938\u0915\u0924\u093e \u0939\u0948\u0964 \u092f\u0939 \u0936\u094b\u0927 \u092a\u0924\u094d\u0930 \u092a\u0941\u0928\u0930\u093e\u0935\u0943\u0924\u094d\u0924 \u0917\u094d\u0932\u093f\u092f\u094b\u092c\u094d\u0932\u093e\u0938\u094d\u091f\u094b\u092e\u093e \u0915\u0947 \u0932\u093f\u090f \u0935\u093f\u092d\u0947\u0926\u0928-\u0906\u0927\u093e\u0930\u093f\u0924 \u0915\u0948\u0902\u0938\u0930 \u0935\u093f\u0930\u094b\u0927\u0940 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0915\u0947 \u0930\u0942\u092a \u092e\u0947\u0902 \u0938\u094d\u0925\u093e\u0928\u0940\u092f \u0930\u0942\u092a \u0938\u0947 \u0907\u0902\u091c\u0947\u0915\u094d\u091f \u092e\u093e\u0928\u0935 \u092a\u0941\u0928\u0930\u094d\u0938\u0902\u092f\u0941\u0915\u094d\u0924 BMP4 (hrBMP4) \u0915\u093e \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0915\u0930\u0928\u0947 \u0935\u093e\u0932\u093e \u0935\u093f\u0936\u094d\u0935 \u0915\u093e \u092a\u0939\u0932\u093e \u092e\u093e\u0928\u0935 \u092a\u094d\u0930\u0925\u092e \u091a\u0930\u0923 (\u092b\u0947\u091c 1) \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092a\u094d\u0930\u0938\u094d\u0924\u0941\u0924 \u0915\u0930\u0924\u093e \u0939\u0948\u0964<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u092f\u0939 \u0905\u0902\u0924\u0930\u094d\u0930\u093e\u0937\u094d\u091f\u094d\u0930\u0940\u092f \u092c\u0939\u0941-\u0915\u0947\u0902\u0926\u094d\u0930 \u0913\u092a\u0928-\u0932\u0947\u092c\u0932 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092e\u093e\u0928\u0915 3+3 \u0916\u0941\u0930\u093e\u0915 \u0935\u0943\u0926\u094d\u0927\u093f \u0921\u093f\u091c\u093e\u0907\u0928 \u0915\u093e \u0909\u092a\u092f\u094b\u0917 \u0915\u0930\u0924\u093e \u0939\u0948, \u091c\u093f\u0938\u092e\u0947\u0902 15 \u0935\u092f\u0938\u094d\u0915 \u0930\u094b\u0917\u0940 \u092d\u0930\u094d\u0924\u0940 \u0915\u093f\u090f \u0917\u090f \u091c\u093f\u0928\u0915\u093e \u0917\u094d\u0932\u093f\u092f\u094b\u092c\u094d\u0932\u093e\u0938\u094d\u091f\u094b\u092e\u093e \u092e\u093e\u0928\u0915 \u0915\u0940\u092e\u094b\u0930\u0947\u0921\u093f\u090f\u0936\u0928 \u0915\u0947 \u092c\u093e\u0926 \u0926\u094b\u092c\u093e\u0930\u093e \u0909\u092d\u0930 \u0917\u092f\u093e \u0925\u093e\u0964 \u092a\u093e\u0924\u094d\u0930 \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u0915\u093e \u0926\u0948\u0928\u093f\u0915 \u0915\u093e\u0930\u094d\u092f \u0915\u094d\u0937\u092e\u0924\u093e \u0905\u091a\u094d\u091b\u0940 \u0925\u0940 (\u0915\u0930\u0928\u094b\u092b\u094d\u0938\u094d\u0915\u0940 \u0938\u094d\u0915\u094b\u0930 &gt;70) \u0914\u0930 \u092e\u0938\u094d\u0924\u093f\u0937\u094d\u0915 \u092e\u0947\u0902 \u0938\u0942\u091c\u0928 \u0938\u0940\u092e\u093f\u0924 \u0925\u0940\u0964 \u0921\u0949\u0915\u094d\u091f\u0930\u094b\u0902 \u0928\u0947 \u091f\u094d\u092f\u0942\u092e\u0930 \u0915\u0947 \u0905\u0902\u0926\u0930 \u0914\u0930 \u0906\u0938\u092a\u093e\u0938 \u092a\u0924\u0932\u0940 \u0915\u0948\u0925\u0947\u091f\u0930 \u0932\u0917\u093e\u090f, \u091c\u093f\u0938\u0938\u0947 \u0915\u0928\u094d\u0935\u0947\u0915\u094d\u0936\u0928 \u090f\u0928\u0939\u093e\u0902\u0938\u094d\u0921 \u0921\u093f\u0932\u0940\u0935\u0930\u0940 (CED) \u0915\u0940 \u0924\u0915\u0928\u0940\u0915 \u0905\u092a\u0928\u093e\u0908 \u0917\u0908\u0964 \u092f\u0939 \u0927\u0940\u092e\u093e, \u0926\u092c\u093e\u0935-\u091a\u093e\u0932\u093f\u0924 \u0938\u0902\u0915\u094d\u0930\u092e\u0923 \u0924\u0915\u0928\u0940\u0915 \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0907\u0902\u091c\u0947\u0915\u094d\u0936\u0928 \u0915\u0940 \u0924\u0941\u0932\u0928\u093e \u092e\u0947\u0902 \u0926\u0935\u093e \u0915\u094b \u092e\u0938\u094d\u0924\u093f\u0937\u094d\u0915 \u0915\u0947 \u090a\u0924\u0915\u094b\u0902 \u092e\u0947\u0902 \u0917\u0939\u0930\u093e\u0908 \u0924\u0915 \u092b\u0948\u0932\u093e\u0924\u0940 \u0939\u0948\u0964 \u092a\u093e\u0902\u091a \u0916\u0941\u0930\u093e\u0915 \u0938\u092e\u0942\u0939 (\u092a\u094d\u0930\u0924\u094d\u092f\u0947\u0915 \u092e\u0947\u0902 \u0924\u0940\u0928 \u0930\u094b\u0917\u0940) \u0925\u0947 \u091c\u093f\u0928\u094d\u0939\u0947\u0902 0.5 \u092e\u093f\u0932\u0940\u0917\u094d\u0930\u093e\u092e \u0938\u0947 18 \u092e\u093f\u0932\u0940\u0917\u094d\u0930\u093e\u092e \u0924\u0915 hrBMP4 \u0915\u0940 \u0905\u0932\u0917-\u0905\u0932\u0917 \u0916\u0941\u0930\u093e\u0915\u0947\u0902 \u0926\u0940 \u0917\u0908\u0902, \u091c\u093f\u0928\u094d\u0939\u0947\u0902 \u0932\u0917\u093e\u0924\u093e\u0930 4 \u0938\u0947 6 \u0926\u093f\u0928\u094b\u0902 \u0924\u0915 \u0938\u0902\u0915\u094d\u0930\u092e\u093f\u0924 \u0915\u093f\u092f\u093e \u0917\u092f\u093e\u0964 \u0936\u094b\u0927\u0915\u0930\u094d\u0924\u093e\u0913\u0902 \u0928\u0947 \u0938\u0941\u0930\u0915\u094d\u0937\u093e, \u0905\u0927\u093f\u0915\u0924\u092e \u0938\u0939\u0928\u0940\u092f \u0916\u0941\u0930\u093e\u0915 (MTD), \u0930\u0915\u094d\u0924 \u092e\u0947\u0902 hrBMP4 \u0915\u093e \u0938\u094d\u0924\u0930, MRI \u0938\u0947 \u091f\u094d\u092f\u0942\u092e\u0930 \u092e\u0947\u0902 \u092c\u0926\u0932\u093e\u0935, \u091c\u0940\u0935\u093f\u0924 \u0930\u0939\u0928\u0947 \u0915\u0940 \u0905\u0935\u0927\u093f \u0914\u0930 \u091c\u0940\u0935\u0928 \u0915\u0940 \u0917\u0941\u0923\u0935\u0924\u094d\u0924\u093e \u0915\u094b \u0905\u0927\u093f\u0915\u0924\u092e 57 \u092e\u0939\u0940\u0928\u094b\u0902 \u0924\u0915 \u091f\u094d\u0930\u0948\u0915 \u0915\u093f\u092f\u093e\u0964<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0915\u0941\u0932 \u092e\u093f\u0932\u093e\u0915\u0930 \u092f\u0939 \u0909\u092a\u091a\u093e\u0930 \u092c\u0939\u0941\u0924 \u0938\u0941\u0930\u0915\u094d\u0937\u093f\u0924 \u0938\u093e\u092c\u093f\u0924 \u0939\u0941\u0906\u0964 \u0915\u094b\u0908 \u092d\u0940 \u0926\u0935\u093e \u0938\u0947 \u091c\u0941\u0921\u093c\u093e \u0917\u0902\u092d\u0940\u0930 \u0935\u093f\u0937\u093e\u0915\u094d\u0924 \u092a\u094d\u0930\u092d\u093e\u0935 \u092f\u093e \u0916\u0941\u0930\u093e\u0915-\u0938\u0940\u092e\u093f\u0924 \u0926\u0941\u0937\u094d\u092a\u094d\u0930\u092d\u093e\u0935 \u0928\u0939\u0940\u0902 \u0926\u0947\u0916\u093e \u0917\u092f\u093e, \u0907\u0938\u0932\u093f\u090f \u0905\u0927\u093f\u0915\u0924\u092e \u0938\u0939\u0928\u0940\u092f \u0916\u0941\u0930\u093e\u0915 \u0928\u093f\u0930\u094d\u0927\u093e\u0930\u093f\u0924 \u0928\u0939\u0940\u0902 \u0939\u094b \u0938\u0915\u0940\u0964 \u0905\u0927\u093f\u0915\u093e\u0902\u0936 \u0939\u0932\u094d\u0915\u0947 \u0938\u0947 \u092e\u0927\u094d\u092f\u092e \u0932\u0915\u094d\u0937\u0923 (\u0938\u093f\u0930\u0926\u0930\u094d\u0926, \u0909\u0932\u094d\u091f\u0940, \u0936\u0930\u0940\u0930 \u0915\u093e 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class=\"wp-block-paragraph\">\u0909\u0932\u094d\u0932\u0947\u0916\u0928\u0940\u092f \u092c\u093e\u0924 \u092f\u0939 \u0939\u0948 \u0915\u093f 15 \u092e\u0947\u0902 \u0938\u0947 3 \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u091f\u094d\u092f\u0942\u092e\u0930 \u092e\u0947\u0902 \u0932\u0902\u092c\u0947 \u0938\u092e\u092f \u0924\u0915 \u0938\u093f\u0915\u0941\u0921\u093c\u093e\u0935 \u0926\u0947\u0916\u093e \u0917\u092f\u093e, \u091c\u093f\u0928\u092e\u0947\u0902 \u0938\u0947 \u0926\u094b \u092e\u0947\u0902 \u092a\u0942\u0930\u094d\u0923 \u0938\u094d\u0925\u093e\u0928\u0940\u092f \u091f\u094d\u092f\u0942\u092e\u0930 \u0909\u0928\u094d\u092e\u0942\u0932\u0928 \u0939\u0941\u0906 \u0914\u0930 \u0935\u0947 \u0905\u0938\u093e\u0927\u093e\u0930\u0923 \u0930\u0942\u092a \u0938\u0947 \u0932\u0902\u092c\u0947 \u0938\u092e\u092f \u0924\u0915 \u091c\u0940\u0935\u093f\u0924 \u0930\u0939\u0947\u0964 \u0930\u094b\u0917\u0940 2 \u0915\u094b \u0926\u0942\u0938\u0930\u0940 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\u0938\u0947 \u0938\u094d\u0925\u093e\u0928\u0940\u092f hrBMP4 \u092a\u0941\u0928\u0930\u093e\u0935\u0943\u0924\u094d\u0924 \u0917\u094d\u0932\u093f\u092f\u094b\u092c\u094d\u0932\u093e\u0938\u094d\u091f\u094b\u092e\u093e \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u0938\u0941\u0930\u0915\u094d\u0937\u093f\u0924 \u0914\u0930 \u0938\u0939\u0928\u0940\u092f \u0939\u0948\u0964 \u0926\u094b \u0932\u0902\u092c\u0940 \u0905\u0935\u0927\u093f \u0924\u0915 \u092a\u0942\u0930\u094d\u0923 \u091f\u094d\u092f\u0942\u092e\u0930 \u0909\u0928\u094d\u092e\u0942\u0932\u0928 \u0915\u0947 \u092e\u093e\u092e\u0932\u0947 \u0938\u094d\u091f\u0947\u092e \u0915\u094b\u0936\u093f\u0915\u093e\u0913\u0902 \u0915\u094b \u0932\u0915\u094d\u0937\u093f\u0924 \u0915\u0930\u0928\u0947 \u0935\u093e\u0932\u0940 \u0935\u093f\u092d\u0947\u0926\u0928 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0915\u0940 \u0935\u0948\u0927\u0924\u093e \u0915\u094b \u092e\u091c\u092c\u0942\u0924 \u0915\u0930\u0924\u0947 \u0939\u0948\u0902\u0964 \u0907\u0938 \u0905\u0927\u094d\u092f\u092f\u0928 \u0915\u0940 \u092e\u0941\u0916\u094d\u092f \u0938\u0940\u092e\u093e\u090f\u0902 \u0939\u0948\u0902 CED \u0915\u0948\u0925\u0947\u091f\u0930 \u0938\u0947 \u091f\u094d\u092f\u0942\u092e\u0930 \u0915\u093e \u0905\u0927\u0942\u0930\u093e \u0915\u0935\u0930\u0947\u091c \u0914\u0930 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0936\u0941\u0930\u0942 \u0939\u094b\u0928\u0947 \u0938\u0947 \u092a\u0939\u0932\u0947 \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u0915\u0947 \u0906\u0923\u0935\u093f\u0915 \u0935\u0930\u094d\u0917\u0940\u0915\u0930\u0923 \u0915\u0940 \u0915\u092e\u0940\u0964 \u091f\u094d\u092f\u0942\u092e\u0930 \u0935\u093f\u0930\u094b\u0927\u0940 \u0906\u0936\u093e\u091c\u0928\u0915 \u092a\u0930\u093f\u0923\u093e\u092e \u092c\u0921\u093c\u0947 \u0926\u0942\u0938\u0930\u0947 \u091a\u0930\u0923 (\u092b\u0947\u091c 2) \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0936\u0941\u0930\u0942 \u0915\u0930\u0928\u0947 \u0915\u093e \u0938\u092e\u0930\u094d\u0925\u0928 \u0915\u0930\u0924\u0947 \u0939\u0948\u0902, \u091c\u093f\u0938\u092e\u0947\u0902 hrBMP4 \u0915\u0940 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u0940\u092f \u0915\u094d\u0937\u092e\u0924\u093e \u0915\u094b \u0914\u092a\u091a\u093e\u0930\u093f\u0915 \u0930\u0942\u092a \u0938\u0947 \u091c\u093e\u0902\u091a\u093e \u091c\u093e\u090f\u0917\u093e\u0964 \u0938\u093e\u0925 \u0939\u0940 \u0924\u0915\u0928\u0940\u0915\u0940 \u0938\u0941\u0927\u093e\u0930\u094b\u0902 \u0938\u0947 \u0926\u0935\u093e \u0915\u093e \u091f\u094d\u092f\u0942\u092e\u0930 \u0915\u0935\u0930\u0947\u091c \u092c\u0922\u093c\u093e\u092f\u093e \u091c\u093e\u090f\u0917\u093e \u0914\u0930 \u092a\u0942\u0930\u094d\u0935\u093e\u0928\u0941\u092e\u093e\u0928\u093f\u0924 \u092c\u093e\u092f\u094b\u092e\u093e\u0930\u094d\u0915\u0930\u094b\u0902 \u0915\u0940 \u092e\u0926\u0926 \u0938\u0947 \u0909\u0928 \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u0915\u093e \u091a\u092f\u0928 \u0915\u093f\u092f\u093e \u091c\u093e\u090f\u0917\u093e \u091c\u093f\u0928\u0915\u0947 \u0907\u0938 \u0909\u092a\u091a\u093e\u0930 \u0938\u0947 \u0932\u093e\u092d \u0939\u094b\u0928\u0947 \u0915\u0940 \u0938\u092c\u0938\u0947 \u0905\u0927\u093f\u0915 \u0938\u0902\u092d\u093e\u0935\u0928\u093e \u0939\u0948\u0964<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u091f\u094d\u0930\u093e\u0902\u0938\u0932\u0947\u0936\u0928 \u0928\u094b\u091f<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\u092f\u0939 \u092e\u093e\u0928\u0915 \u0926\u0947\u0935\u0928\u093e\u0917\u0930\u0940 \u0939\u093f\u0928\u094d\u0926\u0940 (\u092d\u093e\u0930\u0924\u0940\u092f \u092a\u094d\u0930\u092f\u0941\u0915\u094d\u0924) \u0905\u0928\u0941\u0935\u093e\u0926 \u0939\u0948, \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0936\u092c\u094d\u0926\u093e\u0935\u0932\u0940 \u0915\u094b \u092d\u093e\u0930\u0924\u0940\u092f \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u092a\u093e\u0920\u094d\u092f\u092a\u0941\u0938\u094d\u0924\u0915\u094b\u0902 \u092e\u0947\u0902 \u092a\u094d\u0930\u091a\u0932\u093f\u0924 \u0936\u092c\u094d\u0926\u094b\u0902 \u0938\u0947 \u0932\u093f\u0916\u093e \u0917\u092f\u093e \u0939\u0948\u0964<\/li>\n\n\n\n<li>\u0924\u0915\u0928\u0940\u0915\u0940 \u0936\u092c\u094d\u0926 \u091c\u0948\u0938\u0947 CED, hrBMP4, MRI, Karnofsky, Lomustine \u0915\u094b \u0935\u0939\u0940 \u0930\u0916\u0915\u0930 \u0939\u093f\u0928\u094d\u0926\u0940 \u092e\u0947\u0902 \u0935\u094d\u092f\u093e\u0916\u094d\u092f\u093e \u0926\u0940 \u0917\u0908 \u0939\u0948\u0964<\/li>\n\n\n\n<li>\u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0938\u0902\u092c\u0902\u0927\u0940 \u0938\u0902\u091c\u094d\u091e\u093e\u090f\u0902 (\u091f\u094d\u092f\u0942\u092e\u0930, \u0938\u094d\u091f\u0947\u092e \u0915\u094b\u0936\u093f\u0915\u093e, \u0915\u0940\u092e\u094b\u0925\u0947\u0930\u0947\u092a\u0940, \u0930\u0947\u0921\u093f\u092f\u094b\u0925\u0947\u0930\u0947\u092a\u0940) \u092d\u093e\u0930\u0924\u0940\u092f \u0905\u0938\u094d\u092a\u0924\u093e\u0932\u094b\u0902 \u092e\u0947\u0902 \u0909\u092a\u092f\u094b\u0917\u0940 \u0936\u092c\u094d\u0926\u093e\u0935\u0932\u0940 \u0938\u0947 \u0905\u0928\u0941\u0935\u093e\u0926\u093f\u0924 \u0939\u0948\u0902\u0964<\/li>\n<\/ol>\n\n\n<div class=\"woocommerce \"><ul class=\"products columns-4\">\r\n<li class=\"product type-product post-24 status-publish first instock product_cat-uncategorized has-post-thumbnail sale downloadable virtual purchasable product-type-simple\">\n\t<a href=\"https:\/\/cancercurecase.com\/?product=pdflink\" class=\"woocommerce-LoopProduct-link woocommerce-loop-product__link\">\n\t<span class=\"onsale\">Sale!<\/span>\n\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-300x300.png\" class=\"attachment-woocommerce_thumbnail size-woocommerce_thumbnail\" alt=\"Download PDF\" srcset=\"https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-300x300.png 300w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-100x100.png 100w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-150x150.png 150w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon.png 440w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><h2 class=\"woocommerce-loop-product__title\">1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured<\/h2>\n\t<span class=\"price\"><del aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\"><bdi><span class=\"woocommerce-Price-currencySymbol\">&#36;<\/span>99.00<\/bdi><\/span><\/del> <span class=\"screen-reader-text\">Original price was: &#036;99.00.<\/span><ins aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\"><bdi><span class=\"woocommerce-Price-currencySymbol\">&#36;<\/span>69.00<\/bdi><\/span><\/ins><span class=\"screen-reader-text\">Current price is: &#036;69.00.<\/span><\/span>\n<\/a><a href=\"\/index.php?rest_route=%2Fwp%2Fv2%2Fposts%2F1&#038;add-to-cart=24\" aria-describedby=\"woocommerce_loop_add_to_cart_link_describedby_24\" data-quantity=\"1\" class=\"button product_type_simple add_to_cart_button ajax_add_to_cart\" data-product_id=\"24\" data-product_sku=\"\" aria-label=\"Add to cart: &ldquo;1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured&rdquo;\" rel=\"nofollow\" data-success_message=\"&ldquo;1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured&rdquo; has been added to your cart\" role=\"button\">Add to cart<\/a>\t<span id=\"woocommerce_loop_add_to_cart_link_describedby_24\" class=\"screen-reader-text\">\n\t\t\t<\/span>\n<\/li>\n<\/ul>\n<\/div>\n<h5>Membeli teks lengkap PDF dalam bahasa Inggris dan terjemahan bahasa Indonesia.<\/h5>\n\n\n<h1 class=\"wp-block-heading\">Uji Coba Pemberian Lokal hrBMP4 untuk Glioblastoma Berulang<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">Glioblastoma merupakan jenis tumor otak paling mematikan, dan selama puluhan tahun pengobatan efektif untuk penyakit ini masih sangat terbatas. Pertumbuhan serta kekambuhan tumor ini sangat bergantung pada sel batang glioblastoma (GSC), yang tahan terhadap kemoterapi dan radioterapi standar. Protein Morfogenetik Tulang 4 (BMP4) terbukti mampu mendorong sel batang ganas ini untuk matang dan kehilangan kemampuan membentuk tumor, berdasarkan hasil penelitian laboratorium dan model hewan. Artikel ini melaporkan uji coba Fase 1 pertama di dunia yang menguji rekombinan BMP4 manusia (hrBMP4) yang disuntikkan secara lokal sebagai terapi antikanker berbasis diferensiasi pada pasien glioblastoma berulang.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Uji coba terbuka lintas pusat internasional ini menggunakan desain peningkatan dosis standar 3+3, dengan merekrut 15 pasien dewasa yang glioblastomanya kambuh setelah menjalani kemoradioterapi standar. Pasien yang memenuhi syarat memiliki fungsi aktivitas sehari-hari yang baik (skor Karnofsky &gt;70) dan pembengkakan otak yang terbatas. Dokter memasang kateter halus ke dalam dan di sekitar tumor untuk Metode Pemberian Konveksi Terarah (CED)\u2014infus lambat bertekanan yang dapat menyebarkan obat jauh ke dalam jaringan otak lebih efektif dibanding suntikan biasa. Terdapat lima kelompok dosis hrBMP4 (0,5 mg hingga 18 mg, masing-masing berisi tiga pasien) yang menerima infus berkelanjutan selama 4\u20136 hari. Peneliti memantau aspek keamanan, dosis toleransi maksimal (MTD), kadar hrBMP4 dalam darah, perubahan tumor melalui MRI, tingkat kelangsungan hidup, serta kualitas hidup pasien hingga masa tindak lanjut 57 bulan.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Secara keseluruhan, pengobatan ini sangat aman. Tidak ditemukan efek racun berat terkait obat maupun efek samping pembatas dosis, sehingga batas dosis toleransi maksimal tidak tercapai. Sebagian besar gejala ringan hingga sedang (sakit kepala, muntah, kelemahan anggota tubuh) berasal dari prosedur pemasangan kateter atau obat steroid, bukan dari hrBMP4. Hanya tiga pasien yang mengalami peningkatan sementara kadar hrBMP4 dalam darah, namun kadar tersebut kembali normal dalam waktu empat minggu tanpa menimbulkan bahaya.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Yang patut diperhatikan, 3 dari 15 pasien mengalami penyusutan tumor yang bertahan lama, termasuk dua pasien dengan respons lengkap tumor lokal dan kelangsungan hidup jangka panjang yang luar biasa. Pasien nomor 2 menerima dosis hrBMP4 terendah sebesar 0,5 mg untuk glioblastoma temporal yang kambuh kedua kalinya. Setelah infus, tumor yang dirawat perlahan menyusut secara konsisten selama 12 bulan tanpa muncul pertumbuhan tumor baru. Pada tindak lanjut bulan ke-57, pasien ini tetap stabil secara klinis dengan peningkatan fungsi gerak dan keseimbangan tubuh, serta tidak pernah memerlukan kemoterapi atau operasi tambahan setelahnya. Pasien nomor 15 menerima dosis tertinggi 18 mg hrBMP4 untuk kekambuhan di lobus parietal yang resisten terhadap pengobatan. Lesi tumor perlahan memudar selama 18 bulan dan mencapai pembersihan penuh yang terlihat pada hasil radiologi. Hingga 30 bulan pasca pengobatan, area tumor yang diinfus tetap hilang sepenuhnya, meskipun tumor terpisah di lobus frontal yang tidak dirawat kemudian berkembang. Pasien ketiga hanya mengalami penyusutan sebagian tumor sebelum akhirnya tumor kembali berkembang. Temuan penting lainnya: kekambuhan tumor hampir selalu muncul di area otak yang tidak terjangkau oleh infus hrBMP4, sedangkan wilayah yang terpenetrasi obat jarang sekali mengalami pertumbuhan tumor baru. Median kelangsungan hidup keseluruhan seluruh pasien mencapai 7 bulan, lebih lama dibandingkan rata-rata 5,6 bulan dari lomustin, kemoterapi lini kedua yang umum digunakan.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Studi pertama pada manusia yang perintis ini membuktikan bahwa pemberian hrBMP4 secara lokal melalui CED aman dan dapat ditoleransi pasien glioblastoma berulang. Dua kasus remisi lengkap jangka panjang secara kuat memvalidasi konsep terapi diferensiasi yang menargetkan sel batang glioblastoma. Keterbatasan utama penelitian ini adalah cakupan tumor yang tidak sempurna oleh kateter CED serta tidak adanya skrining molekuler pasien sebelum penelitian. Sinyal efek antikanker yang menjanjikan mendukung pelaksanaan uji coba Fase 2 skala besar untuk menguji efektivitas terapi hrBMP4 secara formal, disertai perbaikan teknis guna memperluas cakupan obat dan biomarker prediktif untuk memilih pasien yang paling berpotensi merespons pengobatan.<\/p>\n\n\n<div class=\"woocommerce \"><ul class=\"products columns-4\">\r\n<li class=\"product type-product post-24 status-publish first instock product_cat-uncategorized has-post-thumbnail sale downloadable virtual purchasable product-type-simple\">\n\t<a href=\"https:\/\/cancercurecase.com\/?product=pdflink\" class=\"woocommerce-LoopProduct-link woocommerce-loop-product__link\">\n\t<span class=\"onsale\">Sale!<\/span>\n\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-300x300.png\" class=\"attachment-woocommerce_thumbnail size-woocommerce_thumbnail\" alt=\"Download PDF\" srcset=\"https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-300x300.png 300w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-100x100.png 100w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-150x150.png 150w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon.png 440w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><h2 class=\"woocommerce-loop-product__title\">1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured<\/h2>\n\t<span class=\"price\"><del aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\"><bdi><span class=\"woocommerce-Price-currencySymbol\">&#36;<\/span>99.00<\/bdi><\/span><\/del> <span class=\"screen-reader-text\">Original price was: &#036;99.00.<\/span><ins aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\"><bdi><span class=\"woocommerce-Price-currencySymbol\">&#36;<\/span>69.00<\/bdi><\/span><\/ins><span class=\"screen-reader-text\">Current price is: &#036;69.00.<\/span><\/span>\n<\/a><a href=\"\/index.php?rest_route=%2Fwp%2Fv2%2Fposts%2F1&#038;add-to-cart=24\" aria-describedby=\"woocommerce_loop_add_to_cart_link_describedby_24\" data-quantity=\"1\" class=\"button product_type_simple add_to_cart_button ajax_add_to_cart\" data-product_id=\"24\" data-product_sku=\"\" aria-label=\"Add to cart: &ldquo;1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured&rdquo;\" rel=\"nofollow\" data-success_message=\"&ldquo;1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured&rdquo; has been added to your cart\" role=\"button\">Add to cart<\/a>\t<span id=\"woocommerce_loop_add_to_cart_link_describedby_24\" class=\"screen-reader-text\">\n\t\t\t<\/span>\n<\/li>\n<\/ul>\n<\/div>\n<h5>\u0634\u0631\u0627\u0621 \u0627\u0644\u0646\u0635 \u0627\u0644\u0643\u0627\u0645\u0644 \u0628\u0627\u0644\u0644\u063a\u0629 \u0627\u0644\u0625\u0646\u062c\u0644\u064a\u0632\u064a\u0629 \u0628\u0635\u064a\u063a\u0629 PDF \u0648\u062a\u0631\u062c\u0645\u062a\u0647 \u0625\u0644\u0649 \u0627\u0644\u0639\u0631\u0628\u064a\u0629.<\/h5>\n<p><\/p>\n\n<h1 class=\"wp-block-heading\"> \u0627\u0644\u0646\u0642\u0644 \u0625\u0644\u0649 \u0627\u0644\u0644\u063a\u0629 \u0627\u0644\u0639\u0631\u0628\u064a\u0629 \u0627\u0644\u0641\u0635\u062d\u0649 \u0627\u0644\u0639\u0644\u0645\u064a\u0629 \u0627\u0644\u0637\u0628\u064a\u0629 (\u0644\u0644\u0646\u0634\u0631 \u0641\u064a \u0627\u0644\u0645\u062c\u0644\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0629)\n<\/h1>\n\n\n<p class=\"wp-block-paragraph\">\n \u0627\u0644\u0639\u0646\u0648\u0627\u0646\n\u062d\u0642\u0646 \u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0646\u0645\u0648 \u0627\u0644\u0639\u0638\u0645\u064a 4 \u0627\u0644\u0645\u0624\u062a\u0644\u0641 \u0627\u0644\u0628\u0634\u0631\u064a \u0627\u0644\u0645\u0648\u0636\u0639\u064a \u0644\u0648\u0631\u0645 \u0627\u0644\u0623\u0631\u0648\u0645\u0629 \u0627\u0644\u062f\u0628\u0642\u064a\u0629 \u0627\u0644\u0645\u062a\u0643\u0631\u0631: 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\u0627\u0644\u062f\u0648\u0627\u0621\u060c \u0648\u062a\u062d\u062f\u064a\u062f \u0645\u0624\u0634\u0631\u0627\u062a \u062d\u064a\u0648\u064a\u0629 \u062a\u0646\u0628\u0624\u064a\u0629 \u0644\u0627\u062e\u062a\u064a\u0627\u0631 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0623\u0643\u062b\u0631 \u0639\u0631\u0636\u0629 \u0644\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u0639\u0644\u0627\u062c.\n\n\n<\/p>\n\n\n<p><\/p>\n<div class=\"woocommerce \"><ul class=\"products columns-4\">\r\n<li class=\"product type-product post-24 status-publish first instock product_cat-uncategorized has-post-thumbnail sale downloadable virtual purchasable product-type-simple\">\n\t<a href=\"https:\/\/cancercurecase.com\/?product=pdflink\" class=\"woocommerce-LoopProduct-link woocommerce-loop-product__link\">\n\t<span class=\"onsale\">Sale!<\/span>\n\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-300x300.png\" class=\"attachment-woocommerce_thumbnail size-woocommerce_thumbnail\" alt=\"Download PDF\" srcset=\"https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-300x300.png 300w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-100x100.png 100w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-150x150.png 150w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon.png 440w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><h2 class=\"woocommerce-loop-product__title\">1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured<\/h2>\n\t<span class=\"price\"><del aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\"><bdi><span class=\"woocommerce-Price-currencySymbol\">&#36;<\/span>99.00<\/bdi><\/span><\/del> <span class=\"screen-reader-text\">Original price was: &#036;99.00.<\/span><ins aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\"><bdi><span class=\"woocommerce-Price-currencySymbol\">&#36;<\/span>69.00<\/bdi><\/span><\/ins><span class=\"screen-reader-text\">Current price is: &#036;69.00.<\/span><\/span>\n<\/a><a href=\"\/index.php?rest_route=%2Fwp%2Fv2%2Fposts%2F1&#038;add-to-cart=24\" aria-describedby=\"woocommerce_loop_add_to_cart_link_describedby_24\" data-quantity=\"1\" class=\"button product_type_simple add_to_cart_button ajax_add_to_cart\" data-product_id=\"24\" data-product_sku=\"\" aria-label=\"Add to cart: &ldquo;1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured&rdquo;\" rel=\"nofollow\" data-success_message=\"&ldquo;1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured&rdquo; has been added to your cart\" role=\"button\">Add to cart<\/a>\t<span id=\"woocommerce_loop_add_to_cart_link_describedby_24\" class=\"screen-reader-text\">\n\t\t\t<\/span>\n<\/li>\n<\/ul>\n<\/div>\n<h5>Comprar el texto completo en ingl\u00e9s en formato PDF y su traducci\u00f3n al espa\u00f1ol.<\/h5>\n\n\n<h1 class=\"wp-block-heading\">Ensayo de administraci\u00f3n local de hrBMP4 para glioblastoma recurrente<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">El glioblastoma es el tipo de tumor cerebral m\u00e1s letal y, durante d\u00e9cadas, se han contado con muy pocas terapias eficaces. Su crecimiento y recurrencia dependen en gran medida de las c\u00e9lulas madre del glioblastoma (GSC), las cuales son resistentes a la quimiorradioterapia convencional. En estudios de laboratorio y modelos animales, la Prote\u00edna Morfog\u00e9nica \u00d3sea 4 (BMP4) es capaz de inducir la maduraci\u00f3n de estas c\u00e9lulas madre malignas y hacer que pierdan su capacidad de formar tumores. Este art\u00edculo presenta el primer ensayo cl\u00ednico de fase I en seres humanos del mundo que eval\u00faa la administraci\u00f3n local de la BMP4 recombinante humana (hrBMP4), una terapia anticancer\u00edgena basada en la diferenciaci\u00f3n, en pacientes con glioblastoma recurrente.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Se trata de un ensayo abierto, multic\u00e9ntrico e internacional con un dise\u00f1o est\u00e1ndar de escalado de dosis 3+3, en el que se reclutaron 15 pacientes adultos con glioblastoma recidivante tras haber recibido quimiorradioterapia est\u00e1ndar. Los pacientes elegibles presentaban una buena capacidad funcional diaria (puntuaci\u00f3n de Karnofsky superior a 70) y una hinchaz\u00f3n cerebral limitada. Los m\u00e9dicos implantaron cat\u00e9teres finos dentro y alrededor del tumor para realizar la Administraci\u00f3n por Convecci\u00f3n Mejorada (CED): una infusi\u00f3n lenta a presi\u00f3n que distribuye el f\u00e1rmaco profundamente en el tejido cerebral de forma m\u00e1s eficaz que las inyecciones convencionales. Se formaron cinco grupos de dosis de hrBMP4 (desde 0,5 mg hasta 18 mg, con tres pacientes por grupo), que recibieron una infusi\u00f3n continua durante 4 a 6 d\u00edas. Los investigadores monitorizaron la seguridad, la dosis m\u00e1xima tolerada (DMT), los niveles sangu\u00edneos de hrBMP4, las alteraciones tumorales observadas por resonancia magn\u00e9tica (RM), la supervivencia y la calidad de vida de los pacientes durante un seguimiento de hasta 57 meses.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">En general, el tratamiento result\u00f3 muy seguro. No se detectaron toxicidades graves ni efectos adversos limitantes de dosis relacionados con el f\u00e1rmaco, por lo que no se alcanz\u00f3 la dosis m\u00e1xima tolerada. La mayor\u00eda de los s\u00edntomas leves o moderados (dolor de cabeza, v\u00f3mitos, debilidad) se debieron a la cirug\u00eda de implantaci\u00f3n de cat\u00e9teres o a los f\u00e1rmacos esteroideos, no a la hrBMP4. Solo tres pacientes presentaron un aumento transitorio de los niveles sangu\u00edneos de hrBMP4, que volvieron a los valores normales en cuatro semanas sin causar ning\u00fan da\u00f1o.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Destaca que 3 de los 15 pacientes experimentaron una reducci\u00f3n tumoral duradera, entre ellos dos con respuesta tumoral local completa y una supervivencia a largo plazo excepcional. El paciente 2 recibi\u00f3 la dosis m\u00e1s baja de hrBMP4 (0,5 mg) por un glioblastoma temporal en segunda recurrencia. Tras la infusi\u00f3n, el tumor tratado se redujo de forma constante durante 12 meses sin aparici\u00f3n de nuevas lesiones tumorales. En el seguimiento a los 57 meses, el paciente mantuvo una estabilidad cl\u00ednica, con mejora de la movilidad y el equilibrio, y no necesit\u00f3 quimioterapia ni cirug\u00eda adicionales despu\u00e9s. El paciente 15 recibi\u00f3 la dosis m\u00e1xima de 18 mg de hrBMP4 para una recurrencia en el l\u00f3bulo parietal resistente a los tratamientos previos. La lesi\u00f3n se fue reduciendo gradualmente durante 18 meses hasta desaparecer completamente en las im\u00e1genes radiol\u00f3gicas. A los 30 meses despu\u00e9s del tratamiento, la zona del tumor infundido segu\u00eda sin lesiones, aunque otro tumor separado en el l\u00f3bulo frontal, no tratado, termin\u00f3 progresando. El tercer paciente con respuesta solo present\u00f3 una reducci\u00f3n parcial del tumor antes de que este volviera a crecer. Otro hallazgo relevante: la recidiva tumoral aparec\u00eda casi siempre fuera de las regiones cerebrales cubiertas por la infusi\u00f3n de hrBMP4, mientras que las zonas impregnadas por el f\u00e1rmaco casi no presentaban nuevos crecimientos tumorales. La mediana de supervivencia global de todos los pacientes fue de 7 meses, superior a los 5,6 meses habituales con lomustina, la quimioterapia de segunda l\u00ednea m\u00e1s utilizada.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Este ensayo pionero en seres humanos confirma que la administraci\u00f3n local de hrBMP4 mediante CED es segura y tolerable en pacientes con glioblastoma recurrente. Los dos casos de remisi\u00f3n completa a largo plazo avalan firmemente la terapia de diferenciaci\u00f3n dirigida contra las c\u00e9lulas madre del glioblastoma. Sus principales limitaciones son la cobertura tumoral incompleta por los cat\u00e9teres CED y la ausencia de cribado molecular previo en los pacientes. Los resultados anticancer\u00edgenos prometedores respaldan la realizaci\u00f3n de ensayos de fase II de mayor tama\u00f1o para evaluar formalmente la eficacia terap\u00e9utica de la hrBMP4, junto con mejoras t\u00e9cnicas que ampl\u00eden la cobertura del f\u00e1rmaco y el uso de biomarcadores predictivos para seleccionar a los pacientes con mayor probabilidad de responder al tratamiento.<\/p>\n\n\n<div class=\"woocommerce \"><ul class=\"products columns-4\">\r\n<li class=\"product type-product post-24 status-publish first instock product_cat-uncategorized has-post-thumbnail sale downloadable virtual purchasable product-type-simple\">\n\t<a href=\"https:\/\/cancercurecase.com\/?product=pdflink\" class=\"woocommerce-LoopProduct-link woocommerce-loop-product__link\">\n\t<span class=\"onsale\">Sale!<\/span>\n\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-300x300.png\" class=\"attachment-woocommerce_thumbnail size-woocommerce_thumbnail\" alt=\"Download PDF\" srcset=\"https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-300x300.png 300w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-100x100.png 100w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-150x150.png 150w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon.png 440w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><h2 class=\"woocommerce-loop-product__title\">1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured<\/h2>\n\t<span class=\"price\"><del aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\"><bdi><span class=\"woocommerce-Price-currencySymbol\">&#36;<\/span>99.00<\/bdi><\/span><\/del> <span class=\"screen-reader-text\">Original price was: &#036;99.00.<\/span><ins aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\"><bdi><span class=\"woocommerce-Price-currencySymbol\">&#36;<\/span>69.00<\/bdi><\/span><\/ins><span class=\"screen-reader-text\">Current price is: &#036;69.00.<\/span><\/span>\n<\/a><a href=\"\/index.php?rest_route=%2Fwp%2Fv2%2Fposts%2F1&#038;add-to-cart=24\" aria-describedby=\"woocommerce_loop_add_to_cart_link_describedby_24\" data-quantity=\"1\" class=\"button product_type_simple add_to_cart_button ajax_add_to_cart\" data-product_id=\"24\" data-product_sku=\"\" aria-label=\"Add to cart: &ldquo;1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured&rdquo;\" rel=\"nofollow\" data-success_message=\"&ldquo;1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured&rdquo; has been added to your cart\" role=\"button\">Add to cart<\/a>\t<span id=\"woocommerce_loop_add_to_cart_link_describedby_24\" class=\"screen-reader-text\">\n\t\t\t<\/span>\n<\/li>\n<\/ul>\n<\/div>\n<h5>Compre o texto em PDF, em ingl\u00eas e tradu\u00e7\u00e3o em portugu\u00eas.<\/h5>\n\n\n<h1 class=\"wp-block-heading\">Ensaio de Administra\u00e7\u00e3o Local de hrBMP4 para Glioblastoma Recorrente<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">O glioblastoma \u00e9 o tipo de tumor cerebral mais letal, e h\u00e1 d\u00e9cadas existem poucas terapias eficazes para ele. Seu crescimento e recorr\u00eancia dependem fortemente das c\u00e9lulas-tronco do glioblastoma (CTG), que s\u00e3o resistentes \u00e0 quimiorradioterapia convencional. A Prote\u00edna Morfogen\u00e9tica \u00d3ssea 4 (BMP4) consegue induzir a matura\u00e7\u00e3o dessas c\u00e9lulas-tronco malignas e fazer com que percam a capacidade de formar tumores, conforme demonstrado em estudos laboratoriais e modelos animais. Este artigo descreve o primeiro ensaio cl\u00ednico de Fase 1 em seres humanos do mundo que testa a BMP4 recombinante humana (hrBMP4) administrada localmente, como terapia anticancer\u00edgena baseada em diferencia\u00e7\u00e3o, em pacientes com glioblastoma recorrente.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Este ensaio aberto, multic\u00eantrico e internacional seguiu o desenho padr\u00e3o de escalonamento de dose 3+3, com recrutamento de 15 pacientes adultos que apresentaram recidiva do glioblastoma ap\u00f3s receber quimiorradioterapia padr\u00e3o. Os pacientes eleg\u00edveis possu\u00edam boa capacidade funcional di\u00e1ria (escore de Karnofsky &gt;70) e edema cerebral limitado. Os m\u00e9dicos implantaram cateteres finos dentro e ao redor dos tumores para a Entrega por Convec\u00e7\u00e3o Aumentada (CED, na sigla em ingl\u00eas): uma infus\u00e3o lenta impulsionada por press\u00e3o que distribui o medicamento profundamente no tecido cerebral de forma mais eficaz do que inje\u00e7\u00f5es convencionais. Foram estabelecidos cinco grupos de dose de hrBMP4 (0,5 mg a 18 mg, com tr\u00eas pacientes cada um), os quais receberam infus\u00e3o cont\u00ednua por 4 a 6 dias. Os pesquisadores acompanharam a seguran\u00e7a, a dose m\u00e1xima tolerada (DMT), os n\u00edveis sangu\u00edneos de hrBMP4, as altera\u00e7\u00f5es tumorais por resson\u00e2ncia magn\u00e9tica (RM), a sobrevida e a qualidade de vida dos pacientes por at\u00e9 57 meses.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">O tratamento demonstrou ser amplamente seguro. N\u00e3o foram observados efeitos t\u00f3xicos graves relacionados ao medicamento nem rea\u00e7\u00f5es adversas limitantes de dose, logo n\u00e3o foi poss\u00edvel determinar a DMT. A maioria dos sintomas leves a moderados (dor de cabe\u00e7a, v\u00f4mitos, fraqueza) decorreu da cirurgia de implanta\u00e7\u00e3o dos cateteres ou do uso de corticosteroides, n\u00e3o da hrBMP4. Apenas tr\u00eas pacientes apresentaram eleva\u00e7\u00e3o tempor\u00e1ria dos n\u00edveis sangu\u00edneos de hrBMP4, os quais retornaram aos valores basais em quatro semanas sem causar danos.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Destaca-se que 3 dos 15 pacientes apresentaram redu\u00e7\u00e3o tumoral duradoura, incluindo dois casos de resposta tumoral local completa com sobrevida excepcionalmente prolongada. O Paciente 2 recebeu a menor dose de hrBMP4 (0,5 mg) para um glioblastoma temporal com segunda recidiva. Ap\u00f3s a infus\u00e3o, o tumor tratado diminuiu gradualmente e de forma constante ao longo de 12 meses, sem aparecimento de novas les\u00f5es tumorais. No acompanhamento aos 57 meses, o paciente manteve quadro cl\u00ednico est\u00e1vel, com melhora da motricidade e do equil\u00edbrio, n\u00e3o necessitando de quimioterapia ou cirurgia complementar posteriormente. O Paciente 15 recebeu a dose m\u00e1xima de 18 mg de hrBMP4 para uma recidiva no lobo parietal resistente aos tratamentos anteriores. A les\u00e3o regrediu lentamente ao longo de 18 meses, atingindo remiss\u00e3o completa vis\u00edvel nos exames de imagem. Trinta meses ap\u00f3s o tratamento, a \u00e1rea do tumor infundido permaneceu totalmente desaparecida, embora um tumor separado no lobo frontal, n\u00e3o tratado, tenha evolu\u00eddo posteriormente. O terceiro paciente respondente apresentou apenas redu\u00e7\u00e3o parcial do tumor antes da progress\u00e3o da doen\u00e7a. Outro dado relevante: a recidiva tumoral quase sempre surgiu em regi\u00f5es cerebrais n\u00e3o cobertas pela infus\u00e3o de hrBMP4, enquanto as \u00e1reas permeadas pelo medicamento raramente apresentavam novo crescimento tumoral. A mediana de sobrevida global de todos os pacientes foi de 7 meses, superior aos 5,6 meses t\u00edpicos da lomustina, quimioterapia de segunda linha amplamente utilizada.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Este estudo pioneiro, o primeiro realizado em seres humanos, comprova que a administra\u00e7\u00e3o local de hrBMP4 por meio da CED \u00e9 segura e bem tolerada por pacientes com glioblastoma recorrente. Os dois casos de remiss\u00e3o completa de longa dura\u00e7\u00e3o validam fortemente a terapia de diferencia\u00e7\u00e3o direcionada \u00e0s c\u00e9lulas-tronco do glioblastoma. Suas principais limita\u00e7\u00f5es s\u00e3o a cobertura tumoral incompleta pelos cateteres de CED e a aus\u00eancia de triagem molecular dos pacientes antes do in\u00edcio do ensaio. Os resultados anticancer\u00edgenos promissores apoiam a realiza\u00e7\u00e3o de ensaios de Fase 2 de maior porte para avaliar formalmente o potencial terap\u00eautico da hrBMP4, aliados a melhorias t\u00e9cnicas para ampliar a cobertura medicamentosa e o uso de biomarcadores preditivos para selecionar os pacientes com maior probabilidade de responder ao tratamento.<\/p>\n\n\n<div class=\"woocommerce \"><ul class=\"products columns-4\">\r\n<li class=\"product type-product post-24 status-publish first instock product_cat-uncategorized has-post-thumbnail sale downloadable virtual purchasable product-type-simple\">\n\t<a href=\"https:\/\/cancercurecase.com\/?product=pdflink\" class=\"woocommerce-LoopProduct-link woocommerce-loop-product__link\">\n\t<span class=\"onsale\">Sale!<\/span>\n\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-300x300.png\" class=\"attachment-woocommerce_thumbnail size-woocommerce_thumbnail\" alt=\"Download PDF\" srcset=\"https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-300x300.png 300w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-100x100.png 100w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-150x150.png 150w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon.png 440w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><h2 class=\"woocommerce-loop-product__title\">1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured<\/h2>\n\t<span class=\"price\"><del aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\"><bdi><span class=\"woocommerce-Price-currencySymbol\">&#36;<\/span>99.00<\/bdi><\/span><\/del> <span class=\"screen-reader-text\">Original price was: &#036;99.00.<\/span><ins aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\"><bdi><span class=\"woocommerce-Price-currencySymbol\">&#36;<\/span>69.00<\/bdi><\/span><\/ins><span class=\"screen-reader-text\">Current price is: &#036;69.00.<\/span><\/span>\n<\/a><a href=\"\/index.php?rest_route=%2Fwp%2Fv2%2Fposts%2F1&#038;add-to-cart=24\" aria-describedby=\"woocommerce_loop_add_to_cart_link_describedby_24\" data-quantity=\"1\" class=\"button product_type_simple add_to_cart_button ajax_add_to_cart\" data-product_id=\"24\" data-product_sku=\"\" aria-label=\"Add to cart: &ldquo;1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured&rdquo;\" rel=\"nofollow\" data-success_message=\"&ldquo;1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured&rdquo; has been added to your cart\" role=\"button\">Add to cart<\/a>\t<span id=\"woocommerce_loop_add_to_cart_link_describedby_24\" class=\"screen-reader-text\">\n\t\t\t<\/span>\n<\/li>\n<\/ul>\n<\/div>\n<h5>Acheter le texte int\u00e9gral en anglais PDF et sa traduction en fran\u00e7ais.<\/h5>\n\n\n<h1 class=\"wp-block-heading\">Essai sur l\u2019administration locale de la rhBMP4 dans le glioblastome r\u00e9current<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">Le glioblastome est la forme de tumeur c\u00e9r\u00e9brale la plus mortelle, et les traitements efficaces contre cette maladie restent tr\u00e8s limit\u00e9s depuis plusieurs d\u00e9cennies. Sa croissance et ses r\u00e9cidives d\u00e9pendent largement des cellules souches de glioblastome (CSG), qui r\u00e9sistent aux chimio-radioth\u00e9rapies conventionnelles. La prot\u00e9ine morphog\u00e9n\u00e9tique osseuse 4 (BMP4) est capable de faire m\u00fbrir ces cellules souches malignes et de leur retirer leur capacit\u00e9 \u00e0 former des tumeurs, comme l\u2019ont montr\u00e9 des \u00e9tudes en laboratoire et sur des mod\u00e8les animaux. Cet article pr\u00e9sente le premier essai de phase I sur l\u2019homme au monde qui \u00e9value la rhBMP4 (prot\u00e9ine BMP4 humaine recombinante) inject\u00e9e localement, en tant que th\u00e9rapie anticanc\u00e9reuse reposant sur la diff\u00e9renciation, chez des patients atteints de glioblastome r\u00e9current.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cet essai multicentrique international \u00e0 ouvert a utilis\u00e9 un sch\u00e9ma standard d\u2019escalade de doses 3+3 ; 15 patients adultes dont le glioblastome \u00e9tait revenu apr\u00e8s une chimio-radioth\u00e9rapie standard ont \u00e9t\u00e9 inclus. Les patients \u00e9ligibles pr\u00e9sentaient une bonne autonomie quotidienne (score de Karnofsky sup\u00e9rieur \u00e0 70) et un \u0153d\u00e8me c\u00e9r\u00e9bral limit\u00e9. Des cath\u00e9ters fins ont \u00e9t\u00e9 implant\u00e9s par les m\u00e9decins dans et autour de la tumeur pour r\u00e9aliser une perfusion par d\u00e9livrance convective am\u00e9lior\u00e9e (CED) : une perfusion lente sous pression qui diffuse le m\u00e9dicament profond\u00e9ment dans les tissus c\u00e9r\u00e9braux, bien mieux que des injections classiques. Cinq groupes de doses de rhBMP4 (de 0,5 mg \u00e0 18 mg, trois patients par groupe) ont b\u00e9n\u00e9fici\u00e9 d\u2019une perfusion continue pendant 4 \u00e0 6 jours. Les chercheurs ont surveill\u00e9 la s\u00e9curit\u00e9, la dose maximale tol\u00e9r\u00e9e (DMT), les taux sanguins de rhBMP4, les modifications tumorales \u00e0 l\u2019IRM, la survie et la qualit\u00e9 de vie des patients sur un suivi allant jusqu\u2019\u00e0 57 mois.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Globalement, le traitement s\u2019est r\u00e9v\u00e9l\u00e9 tr\u00e8s s\u00fbr. Aucune toxicit\u00e9 grave li\u00e9e au m\u00e9dicament ni aucun effet ind\u00e9sirable limitant la dose n\u2019ont \u00e9t\u00e9 observ\u00e9s, si bien que la dose maximale tol\u00e9r\u00e9e n\u2019a pas pu \u00eatre d\u00e9termin\u00e9e. La plupart des sympt\u00f4mes l\u00e9gers \u00e0 mod\u00e9r\u00e9s (c\u00e9phal\u00e9es, vomissements, faiblesse motrice) provenaient de la pose des cath\u00e9ters ou des cortico\u00efdes, pas de la rhBMP4. Seuls trois patients ont pr\u00e9sent\u00e9 une \u00e9l\u00e9vation temporaire du taux sanguin de rhBMP4, revenu \u00e0 la normale en l\u2019espace de quatre semaines sans cons\u00e9quence d\u00e9l\u00e9t\u00e8re.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Fait notable, 3 patients sur 15 ont pr\u00e9sent\u00e9 une r\u00e9gression tumorale durable, dont deux r\u00e9pondants complets sur la tumeur locale avec une survie \u00e0 long terme exceptionnelle. Le patient n\u00b02 a re\u00e7u la dose minimale de 0,5 mg de rhBMP4 pour un glioblastome temporal en deuxi\u00e8me r\u00e9cidive. Apr\u00e8s perfusion, la tumeur trait\u00e9e a diminu\u00e9 progressivement et constamment pendant 12 mois sans nouvelle croissance tumorale. Au suivi \u00e0 57 mois, le patient est rest\u00e9 stable sur le plan clinique, avec une am\u00e9lioration de sa motricit\u00e9 et de son \u00e9quilibre, sans avoir eu recours \u00e0 une chimioth\u00e9rapie ou une chirurgie compl\u00e9mentaire par la suite. Le patient n\u00b015 a re\u00e7u la dose maximale de 18 mg de rhBMP4 pour une r\u00e9cidive au lobe pari\u00e9tal r\u00e9sistante aux traitements. La l\u00e9sion a r\u00e9gress\u00e9 graduellement sur 18 mois pour dispara\u00eetre totalement sur les clich\u00e9s radiologiques. Trente mois apr\u00e8s le traitement, cette zone tumorale perfus\u00e9e est rest\u00e9e compl\u00e8tement r\u00e9sorb\u00e9e, m\u00eame si une tumeur frontale distincte non trait\u00e9e a \u00e9volu\u00e9 par la suite. Le troisi\u00e8me r\u00e9pondant n\u2019a connu qu\u2019une r\u00e9gression partielle de la tumeur avant une nouvelle progression. Autre r\u00e9sultat majeur : les r\u00e9cidives tumorales apparaissaient presque syst\u00e9matiquement hors des zones c\u00e9r\u00e9brales couvertes par la perfusion de rhBMP4, tandis que les secteurs impr\u00e9gn\u00e9s du m\u00e9dicament pr\u00e9sentaient tr\u00e8s rarement de nouvelles prolif\u00e9rations tumorales. La m\u00e9diane de survie globale de l\u2019ensemble des patients a atteint 7 mois, sup\u00e9rieure aux 5,6 mois habituels observ\u00e9s avec la lomustine, chimioth\u00e9rapie de seconde ligne couramment utilis\u00e9e.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cette \u00e9tude pionni\u00e8re, la premi\u00e8re r\u00e9alis\u00e9e sur l\u2019homme, confirme que l\u2019administration locale de rhBMP4 par CED est s\u00fbre et bien tol\u00e9r\u00e9e chez les patients atteints de glioblastome r\u00e9current. Les deux r\u00e9missions compl\u00e8tes \u00e0 long terme valident fortement l\u2019int\u00e9r\u00eat des th\u00e9rapies de diff\u00e9renciation ciblant les cellules souches de glioblastome. Ses principales limites sont une couverture tumorale incompl\u00e8te par les cath\u00e9ters de CED et l\u2019absence de criblage mol\u00e9culaire des patients avant l\u2019essai. Les signaux antitumoraux prometteurs justifient le lancement d\u2019essais de phase II plus larges destin\u00e9s \u00e0 \u00e9valuer formellement l\u2019efficacit\u00e9 th\u00e9rapeutique de la rhBMP4, associ\u00e9s \u00e0 des am\u00e9liorations techniques visant \u00e0 \u00e9tendre la diffusion du m\u00e9dicament et \u00e0 l\u2019utilisation de biomarqueurs pr\u00e9dictifs pour s\u00e9lectionner les patients les plus susceptibles de r\u00e9pondre au traitement.<\/p>\n\n\n<div class=\"woocommerce \"><ul class=\"products columns-4\">\r\n<li class=\"product type-product post-24 status-publish first instock product_cat-uncategorized has-post-thumbnail sale downloadable virtual purchasable product-type-simple\">\n\t<a href=\"https:\/\/cancercurecase.com\/?product=pdflink\" class=\"woocommerce-LoopProduct-link woocommerce-loop-product__link\">\n\t<span class=\"onsale\">Sale!<\/span>\n\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-300x300.png\" class=\"attachment-woocommerce_thumbnail size-woocommerce_thumbnail\" alt=\"Download PDF\" srcset=\"https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-300x300.png 300w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-100x100.png 100w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon-150x150.png 150w, https:\/\/cancercurecase.com\/wp-content\/uploads\/2026\/06\/pdficon.png 440w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><h2 class=\"woocommerce-loop-product__title\">1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured<\/h2>\n\t<span class=\"price\"><del aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\"><bdi><span class=\"woocommerce-Price-currencySymbol\">&#36;<\/span>99.00<\/bdi><\/span><\/del> <span class=\"screen-reader-text\">Original price was: &#036;99.00.<\/span><ins aria-hidden=\"true\"><span class=\"woocommerce-Price-amount amount\"><bdi><span class=\"woocommerce-Price-currencySymbol\">&#36;<\/span>69.00<\/bdi><\/span><\/ins><span class=\"screen-reader-text\">Current price is: &#036;69.00.<\/span><\/span>\n<\/a><a href=\"\/index.php?rest_route=%2Fwp%2Fv2%2Fposts%2F1&#038;add-to-cart=24\" aria-describedby=\"woocommerce_loop_add_to_cart_link_describedby_24\" data-quantity=\"1\" class=\"button product_type_simple add_to_cart_button ajax_add_to_cart\" data-product_id=\"24\" data-product_sku=\"\" aria-label=\"Add to cart: &ldquo;1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured&rdquo;\" rel=\"nofollow\" data-success_message=\"&ldquo;1 Local hrBMP4 for Recurrent Glioblastoma: 2 cases cured&rdquo; has been added to your cart\" role=\"button\">Add to cart<\/a>\t<span id=\"woocommerce_loop_add_to_cart_link_describedby_24\" class=\"screen-reader-text\">\n\t\t\t<\/span>\n<\/li>\n<\/ul>\n<\/div>\n<h5>Please Buy the PDF full text in English, along with translations in Chinese, Hindi, Indonesian, Arabic, Spanish, Portuguese, and French.<\/h5>","protected":false},"excerpt":{"rendered":"<p>Please Buy the PDF full text in English, along with translations in Chinese, Hindi, Indonesian, Arabic, Spanish, Portuguese, and French. Glioblastoma is the deadliest type of brain tumor with limited effective therapies over decades. Its growth and recurrence rely heavily on glioblastoma [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":68,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[23],"tags":[40,42],"class_list":["post-1","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-glioblastomaglioma","tag-glioblastoma","tag-hrbmp4"],"_links":{"self":[{"href":"https:\/\/cancercurecase.com\/index.php?rest_route=\/wp\/v2\/posts\/1","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cancercurecase.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cancercurecase.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cancercurecase.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cancercurecase.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1"}],"version-history":[{"count":21,"href":"https:\/\/cancercurecase.com\/index.php?rest_route=\/wp\/v2\/posts\/1\/revisions"}],"predecessor-version":[{"id":118,"href":"https:\/\/cancercurecase.com\/index.php?rest_route=\/wp\/v2\/posts\/1\/revisions\/118"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cancercurecase.com\/index.php?rest_route=\/wp\/v2\/media\/68"}],"wp:attachment":[{"href":"https:\/\/cancercurecase.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cancercurecase.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cancercurecase.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}